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Lon Harris describes using the Ro.co platform to acquire a Wegovy pill prescription, losing nine pounds on a starter dose. Harris will transition from a 1.5 milligram dose to higher strengths to maximize weight loss.
Huberman and Krummel agree scientific progress often involves long periods of frustration and 'dead ends,' with breakthroughs like CRISPR or GLP-1 agonists emerging suddenly from curiosity-driven basic research. These 'orthogonal' discoveries often arise unexpectedly, not from direct problem-solving attempts.
The FDA approved synthetic Exendin-4 (Byetta/Exenatide) in 2005 as the first GLP-1 receptor agonist for type 2 diabetes, paving the way for drugs like semaglutide and tirzepatide.
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