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Menopause-related cognitive impairment can mimic early Alzheimer's symptoms. Devi has treated this successfully with hormone replacement, cholinesterase inhibitors, and targeted brain exercises.
Dr. Devi developed a slow titration protocol for anti-amyloid monoclonal antibodies to reduce ARIA side effects. In her 4/4 APOE patients, this lowered ARIA incidence to 4%, with only one symptomatic case over five years.
Devi's multimodal treatment for dementia includes cholinesterase inhibitors, memantine, valacyclovir for some, immune-modifying drugs, VP shunt for hydrocephalus, and off-label transcranial magnetic stimulation to maintain neuronal connectivity.
Lewy body dementia often coexists with Alzheimer's pathology: autopsy studies show 40% of Alzheimer's patients have Lewy body pathology, and ~30-40% of Lewy body patients have Alzheimer's pathology.
Devi distinguishes Lewy body dementia from Parkinson's by noting Lewy body patients rarely have a classic pill-rolling tremor and often retain insight into their visual hallucinations.
Single-cell atlas data shows many more diverse and bespoke cell types in subcortical steering regions like the hypothalamus than in the cortex. Brown interprets this as evidence that evolution's genomic complexity is spent wiring innate reward functions, not the general learning algorithm.
Brown notes the human genome is only about 3 GB, a small fraction of which codes for the brain. This compactness is plausible if evolution mainly writes 'Python code' for specific reward functions and bootstrapping rules, not the entire learned model.
Goosebumps are caused by erector pili muscles attached to hair follicles, an evolutionary trait from mammals that helps trap warm air or make animals appear larger. For humans, this vestigial response now occurs for non-survival reasons like music or awe.
Priscilla Chan argues that most diseases should be treated as rare diseases due to the uniqueness of each person's biology, contrasting this with the current trial-and-error approach for conditions like hypertension or depression.
Mark Zuckerberg and Priscilla Chan describe the BioHub Network as three hubs: New York focuses on cell engineering, Chicago on tissue building and cell communication, and San Francisco on deep imaging and transcriptomics.
Priscilla Chan explains their 10-to-15-year grand challenges require a credible pathway, someone who can execute, and enough ambiguity to accept risk.
Mark Zuckerberg says the initiative’s AI-driven work involves building frontier AI models alongside frontier biological research to generate purpose-built data sets.
Mark Zuckerberg describes their approach as building a hierarchy of models: a state-of-the-art protein model feeds into a cellular model, which eventually enables systems like a virtual immune system.
Mark Zuckerberg mentions the virtual cell models include VariantFormer for predicting CRISPR edit outcomes, a diffusion model for generating synthetic cell images, and Cryo, their first spatial imaging model.
Priscilla Chan says CellxGene started 10 years ago as a data annotation tool to address bottlenecks in single-cell research and has grown into a public Atlas where the broader community contributed 75% of the millions of cells.
Huberman explains twin studies suggest a genetic component exists in about 40 to 50% of OCD cases.
Huberman identifies the corticostriatothalamic loop as the key neural circuit underlying OCD. Neuroimaging studies and SSRI effects support this circuit model.